Difference Between:
Page-Builder ^_VS Theme-Builder

Page-Builders and Theme-Builders are different kind of plugins. To describe the difference simply, Page Builder  can build individual pages (like Front-Page or any single page), while Theme-Builders can create a permanent,shared layout for Pages,Posts,Categories, etc…
Of course, the best plugin could be Theme & Page Builder (combined together), however, such plugins are quite rare. So, you should choose something desired,flexible THEME, which you can use with your Page-Builder plugin. For that, I recommend to use a flexible theme (view WordPress Themes Full List, especially the paragraph of “Page-Builder compatible Themes“). After installing any theme, you can set any static page as a “Front-Page” and start using a Page-Builder. ( P.S. Conditional Sidebars will also help you much ! Use: Dynamic Widgets or Widget Logic or Widget Options )